abstract：:Depending on the spacing of their positive charges, ionenes, a class of quaternary ammonium polymers, increased the interferon-inducing activity of poly(inosinic acid).poly(cytidylic acid) in mouse L-929 cells, whereas they did not enhance poly(inosinic acid).poly(cytidylic acid) induced interferon production in prima...

journal_title：Antimicrobial agents and chemotherapy

authors： Clercq ED,Janik B,Sommer RG

更新日期：1977-04-01 00:00:00

abstract：:An indirect mouse model was utilized to evaluate the antiviral activity of several compounds against Venezuelan equine encephalomyelitis (VEE) virus infection in mice. Mice were given various dosages of lysine-stabilized polyriboinosinic acid-polyribocytidylic acid, a tilorone analogue, kethoxal, or mepacrine before a...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuehne RW,Pannier WL,Stephen EL

更新日期：1977-04-01 00:00:00

abstract：:Five R plasmids transferred from Asian strains of Vibrio cholerae all proved to be members of compatibility group C. A non-self-transmissible plasmid, stable in V. cholerae, was mobilized for transfer to Escherichia coli K-12 and found to be unstably inherited in that host. Plasmids of group C and P transferred to a w...

journal_title：Antimicrobial agents and chemotherapy

authors： Hedges RW,Vialard JL,Pearson NJ,O'Grady F

更新日期：1977-04-01 00:00:00

abstract：:Gardimycin, a new antibiotic, at 100 mug/ml, specifically inhibited cell wall synthesis and induced accumulation of uridine 5'-diphosphate-N-acetylmur-amylpentapeptide in whole cells of Bacillus subtilis. The antibiotic was active in a particulate enzyme preparation from Bacillus stearothermophilus: 60 mug/ml caused 5...

journal_title：Antimicrobial agents and chemotherapy

authors： Somma S,Merati W,Parenti F

更新日期：1977-03-01 00:00:00

abstract：:An antibiotic-producing pseudomonad was isolated from a seawater sample from a La Jolla, Calif., tidepool. The pseudomonad produces two novel antibacterial compounds, 2-n-pentyl-4-quinolinol and 2-n-heptyl-4-quinolinol. It also synthesizes indole-3-carboxaldehyde, 6-bromoindole-3-carboxaldehyde, and the known antibiot...

journal_title：Antimicrobial agents and chemotherapy

authors： Wratten SJ,Wolfe MS,Andersen RJ,Faulkner DJ

更新日期：1977-03-01 00:00:00

abstract：:The influence of various test meals and fluid volumes on the relative bioavailability of commercial formulations of doxycycline hyclate and tetracycline hydrochloride was studied in healthy human volunteers. Serum levels of tetracycline were uniformly reduced by approximately 50% by all test meals, whereas serum level...

journal_title：Antimicrobial agents and chemotherapy

authors： Welling PG,Koch PA,Lau CC,Craig WA

更新日期：1977-03-01 00:00:00

abstract：:At equivalent oral doses, cefadroxil has a longer serum half-life, slower urinary excretion rate, greater area under the serum level versus time curve than cephalexin or cephradine, and peak serum concentrations that are 75 to 80% those of cephalexin. The calculated, apparent in vivo volume of distribution of cefadrox...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeffer M,Jackson A,Ximenes J,de Menezes JP

更新日期：1977-02-01 00:00:00

abstract：:The following compounds, which possess anti-R-plasmid activity (Hahn and Ciak, 1976) in decreasing order, were shown by viscometric titration to change systematically the superhelical density of closed circular PM2 deoxyribonucleic acid in the manner of intercalators: ethidium bromide, quinacrine, acridine orange, qui...

journal_title：Antimicrobial agents and chemotherapy

authors： Allison RG,Hahn FE

更新日期：1977-02-01 00:00:00

abstract：:Amoxicillin was studied in normal subjects after intravenous, oral, and intramuscular administration of 250-, 500-, and 1,000-mg doses. Serum drug levels were analyzed using a two-compartment open model, as well as area under the curve (AUC) and urinary recovery. The variations of these pharmacokinetic parameters were...

journal_title：Antimicrobial agents and chemotherapy

authors： Spyker DA,Rugloski RJ,Vann RL,O'Brien WM

更新日期：1977-01-01 00:00:00

abstract：:Suboptimal doses of amphotericin B in combination with either rifampin or 5-fluorocytosine were better than single-drug therapy in the treatment of disseminated Aspergillus fumigatus infection in mice. Despite the increased effectiveness of combination therapy, none of the therapeutic regimens we used completely eradi...

journal_title：Antimicrobial agents and chemotherapy

authors： Arroyo J,Medoff G,Kobayashi GS

更新日期：1977-01-01 00:00:00

abstract：:Standardized direct disk diffusion antibiotic susceptibility testing on monomicrobial urine specimens is compared with the Food and Drug Administration method. The direct procedure yields acceptable data and may conserve 24 h in reporting results. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wegner DL,Neblett TR

更新日期：1976-12-01 00:00:00

abstract：:Cefamandole has a broader spectrum and greater potency than the other cephalosporins. It includes Haemophilus influenzae, most strains of Enterobacter, and many strains of indole-positive Proteus and Bacteroides, with a lower minimal inhibitory concentration for Escherichia coli, Klebsiella, etc. Concentrations of dru...

journal_title：Antimicrobial agents and chemotherapy

authors： Griffith RS,Black HR,Brier GL,Wolny JD

更新日期：1976-11-01 00:00:00

abstract：:Although it is generally believed that bactericidal and bacteriostatic drugs should not be combined in vivo, in vitro experiments using the checkerboard dilution technique revealed no antagonism between penicillin/cephalothin and rolitetracycline but rather additive or synergistic activity of either drug combination i...

journal_title：Antimicrobial agents and chemotherapy

authors： Daschner FD

更新日期：1976-11-01 00:00:00

abstract：:R plasmids from chloramphenicol-resistant salmonella from Ontario are shown to belong to the H(2) incompatibility subgroup and to mediate a broad-spectrum, phage inhibition function. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Taylor DE,Grant RB

更新日期：1976-10-01 00:00:00

abstract：:The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller W

更新日期：1976-10-01 00:00:00

abstract：:A number of proflavine (PF)-resistant mutants of Escherichia coli B were also resistant to penicillin and cephalothin. Mutants resistant to 1.0 mM PF were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells. Single-step mutants selected for resistance to either PF or penicillin were also r...

journal_title：Antimicrobial agents and chemotherapy

authors： McKellar RC,McKenzie CN,Kushner KJ

更新日期：1976-10-01 00:00:00

abstract：:R plasmids identified in Pseudomonas aeruginosa strains isolated in our laboratories were classified by their incompatibility characters by using intraspecies conjugation in P. aeruginosa. The fertility factor, FP2, was compatible with R plasmids belonging to all groups, and was classified in a new group. From these d...

journal_title：Antimicrobial agents and chemotherapy

authors： Sagai H,Hasuda K,Iyobe S,Bryan LE,Holloway BW,Mitsuhashi S

更新日期：1976-10-01 00:00:00

abstract：:The physical and nutritional requirements of the antibiotic-producing slime mold Physarum gyrosum were examined to develop a liquid medium for this myxomycete. Liquid culture is desired to expedite a useful scale of production of antibiotic materials for ease of isolation and structure study. Culture conditions were s...

journal_title：Antimicrobial agents and chemotherapy

authors： Taylor RL,Mallette MF

更新日期：1976-10-01 00:00:00

abstract：:Selected cephalosporins, including cefamandole, cephaloridine, cephaloglycin, and cefoxitin, were examined for their ability to inhibit the enzymatic activity of and act as substrates for beta-lactamases produced by Enterobacter cloacae and Staphylococcus aureus. Enzyme inhibition was determined by Michaelis-Menten ki...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahoney DF,Koppel GA,Turner JR

更新日期：1976-09-01 00:00:00

abstract：:The influence of a mission hospital on the evolution of antibiotic resistance in coliform bacteria from a remote antibiotic-free Xhosa community and environment is described. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Burt SJ,Woods DR

更新日期：1976-09-01 00:00:00

abstract：:Inter- and intralaboratory reproducibility of susceptibility testing requires stable control strains. The Food and Drug Administration diffusion procedure recommends the Seattle strains of Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) for this purpose. It was of interest to determine the present...

journal_title：Antimicrobial agents and chemotherapy

authors： Coyle MB,Lampe MF,Aitken CL,Feigl P,Sherris JC

更新日期：1976-09-01 00:00:00

abstract：:An agar dilution method was employed to test the susceptibility of 12 strains of Coccidioides immitis to polymyxin B (PB). After 3 days of incubation, eight strains were markedly inhibited by 5.0 mug of PB per ml and four strains did not grow. PB at 10 mug/ml inhibited the growth of all strains through 20 days of incu...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins MS,Pappagianis D

更新日期：1976-08-01 00:00:00

abstract：:Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailability of cephradine administered intramuscularly and orally. The results indicate that cephradine obeys dose-independent kine...

journal_title：Antimicrobial agents and chemotherapy

authors： Rattie ES,Bernardo PD,Ravin JJ

更新日期：1976-08-01 00:00:00

abstract：:Butylated hydroxytoluene (BHT) is a potent inactivator of the enveloped bacterial virus ø6 at concentrations as low as 3 x 10(-5) M. The viral envelope is not removed by BHT treatment, in contrast to the effects of exposure to the detergent Triton X-100. BHT-treated viruses are morphologically indistinguishable from c...

journal_title：Antimicrobial agents and chemotherapy

authors： Wanda P,Cupp J,Snipes W,Deith A,Rucinsky T,Polish L,Sands J

更新日期：1976-07-01 00:00:00

abstract：:Demethylchlortetracycline and, to a lesser extent, chlortetracycline were found to mediate the in vitro photoinactivation of Venezuelan equine encephalitis virus. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Esparza J,Pina CI,Novo E

更新日期：1976-07-01 00:00:00

abstract：:Subtherapeutic levels of oxytetracycline plus neomycin in animal feeds did not bring about increases in the quantity, prevalence, or shedding of Salmonella typhimurium in swine, calves, or chickens. In fact, the medication generally reduced the proportion of animals carrying S. typhimurium. The medicated groups were f...

journal_title：Antimicrobial agents and chemotherapy

authors： Girard AE,English AR,Evangelisti DG,Lynch JE,Solomons IA

更新日期：1976-07-01 00:00:00

abstract：:Ceftezole, a new cephalosporin derivative, was compared with cefazolin, cephaloridine, and cephalothin. Data obtained indicate that it is a broad-spectrum antibiotic, with almost identical antimicrobial activity against pathogenic organisms isolated from patients. The therapeutic effect of ceftezole on experimental in...

journal_title：Antimicrobial agents and chemotherapy

authors： Nishida M,Murakawa T,Kamimura T,Okada N,Sakamoto H,Fukada S,Nakamoto S,Yokota Y,Miki K

更新日期：1976-07-01 00:00:00

abstract：:Twenty-one patients with serious infections involving anaerobic bacteria were treated with carbenicillin. Multiple anaerobes were involved in 8 cases, and in 10 cases, facultative anaerobes were also isolated. Bacteroides fragilis was isolated in 10 cases. Results were judged excellent in 7 cases, good in 8 cases, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Swenson RM,Lorber B

更新日期：1976-06-01 00:00:00

abstract：:Sixteen clinical fungal isolates were tested for antibiotic susceptibility by using disks impregnated with growth medium and antibiotic. The procedure was easier to perform, less time consuming, and as reliable as other currently available methods. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyer JE

更新日期：1976-06-01 00:00:00

abstract：:A new 3-N-aminoglycoside acetyltransferase is described, which possesses a wider substrate range than any such enzyme so far discovered in clinical isolates of antibiotic-resistant bacteria. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Biddlecome S,Haas M,Davies J,Miller GH,Rane DF,Daniels PJ

更新日期：1976-06-01 00:00:00

abstract：:Sublethal doses of vincristine (VNC) and bacterial lipopolysaccharide (LPS) administered simultaneously to adult male mice resulted in markedly enhanced mortality. All of 10 strains of Pseudomonas aeruginosa tested, 4 of 7 strains of Bacteroides, and 6 of 10 strains of Listeria monocytogenes were able to substitute fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Munson AE,Drummond DC,Adams AC,Bradley SG

更新日期：1976-05-01 00:00:00

abstract：:Properties of a population of carbenicillin- and gentamicin-resistant, tobramycin-susceptible Pseudomonas aeruginosa at Veteran's Administration Hospital, Cincinnati, Ohio, have been followed during a 16-month period. As originally described, the strains were isolated from patients with urinary tract colonizations and...

journal_title：Antimicrobial agents and chemotherapy

authors： Korfhagen TR,Ferrel JA,Menefee CL,Loper JC

更新日期：1976-05-01 00:00:00

abstract：:There has been a marked increase in the resistance of Neisseria gonorrhoeae isolated in Korea to penicillin, ampicillin, and tetracycline. In contrast, there has been no increased resistance to spectinomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilson C,Rose DL,Tramont EC

更新日期：1976-04-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:4,4'-Isopropylidine-bis[2-isopropyl]phenol was found to possess antimicrobial activity against gram-positive bacteria and some fungi, whereas it had no effect on gram-negative organisms. The drug has a potent inhibitory action on the synthesis of cell wall mucopeptides of Bacillus subtilis by inhibiting the enzyme d-g...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimi IR,Shoukry S,Zaki Z

更新日期：1976-04-01 00:00:00

abstract：:Diethylpyrocarbonate (DEPC) treatment of interferon (IF) inducers was studied both in vitro and in vivo. DEPC did not affect the antiviral activity of poly(I.C), statolon, or reovirus in cultured chicken embryo fibroblast cells, but the activities of poly(I.C), statolon, and MU9 replicative form in cultured mouse embr...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamamura Y,Cochran KW

更新日期：1976-04-01 00:00:00

abstract：:Amphotericin B, the principal drug used for treating systemic mycoses, possesses undesirable toxic properties. The ability of this antibiotic to potentiate antifungal activity of other compounds suggests that lower doses of amphotericin B could be used in combination with a second drug without loss of therapeutic effi...

journal_title：Antimicrobial agents and chemotherapy

authors： Huppert M,Pappagianis D,Sun SH,Gleason-Jordan I,Collins MS,Vukovich KR

更新日期：1976-03-01 00:00:00

abstract：:The antibacterial drug nalidixic acid (Nal) can suppress the growth of Candida albicans at levels of the drug normally found in urine. Growth suppression increases as drug levels are increased, and Nal also causes a similar proportional inhibition of the synthesis of all cellular macromolecules. However, growth temper...

journal_title：Antimicrobial agents and chemotherapy

authors： Sobieski RJ,Brewer AR

更新日期：1976-03-01 00:00:00

abstract：:Strains of Pseudomonas aeruginosa resistant to either gentamicin or carbenicillin have been noted since their introduction into clinical use. During a 6-month period, twice-weekly cultures were obtained from all patients treated with either gentamicin or carbenicillin and from all patients with a positive culture for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaman W,Cates C,Snelling CF,Lank B,Ronald AR

更新日期：1976-03-01 00:00:00

abstract：:The binding of penicillin G to a stable L-form from Staphylococcus aureus followed saturation-type kinetics with saturation achieved at 0.75 nmol/ml, the same as with its parent strain. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Suginaka H

更新日期：1976-03-01 00:00:00